Zimadziwika kuti anthu omwe ali ndi matenda oopsa kwambiri amakhala ndi chiopsezo chachikulu cha matenda a myocardial infroction, stroke, kusintha mitsuko ya fundus ndi kulephera kwa chiwindi. Choncho, odwala omwe ali ndi kuwonjezereka kwa magazi, amasonyeza kugwiritsa ntchito mankhwala osokoneza bongo. Malingana ndi kafukufuku wamaphunziro a zachipatala, imodzi mwa mankhwala ogwira ntchito komanso otetezeka ku zitsulo ndi mapiritsi a Lizinopril.
Zisonyezo za kugwiritsa ntchito mapiritsi Lizinopril
Mankhwalawa akulimbikitsidwa pazifukwa zotsatirazi:
- Matenda oopsa (monga mankhwala odziimira okhaokha kapena osakaniza mankhwala osokoneza bongo);
- kuperewera kwa mtima (mwa kuphatikizidwa pamodzi ndi odwala odwala glycosides ndi diuretics);
- matenda oopsa a myocardial infarction (mankhwala oyambirira pa tsiku loyamba kwa odwala omwe ali ndi magawo otetezeka a hemodynamic kuti azisunga magawowa, komanso kupewa kutaya kwa ventricular kusayenerera ndi mtima kulephera);
- odwala matenda a shuga (kuchepa kwa albuminuria kwa odwala omwe ali ndi matenda a shuga a mthupi mwachidziwitso cha magazi ndi odwala omwe ali ndi matenda a shuga a mtundu wachiwiri).
Mapangidwe ndi mankhwala a lisinopril
Mankhwala othandiza a mankhwalawa amachititsa lisinopril dihydrate. Zinthu zothandizira ndizo: lactose, starch, silicon dioxide colloid, talc, magnesium stearate, etc. Lizinopril amamasulidwa m'mapiritsi a 5, 10 ndi 20 mg.
Mankhwalawa ali m'gulu la tizilombo toyambitsa matenda a angiotensin (ACE inhibitors). Amapereka cardioprotective (amachititsa chikhalidwe cha myocardium), vasodilator ndi natriuretic (amachotsa sodium salt ndi mkodzo) kanthu.
Mlingo wa lisinopril
Malinga ndi malangizo ogwiritsiridwa ntchito, mapiritsi a lisinopril amatengedwa kamodzi pa tsiku, mosasamala kanthu kuti chakudya chimadya. Ndibwino kuti mutenge mankhwalawa nthawi yomweyo (makamaka m'mawa).
Mlingo umadalira mtundu wa matenda ndipo akhoza kudziwidwa payekha ndi dokotala yemwe akupezekapo. Choncho, ndi matenda oopsa kwambiri, mlingo woyambirira wa tsiku lililonse, monga lamulo, ndi 10 mg, ndipo mlingo woyenera ndi mlingo wa 20 mg. Mlingo waukulu pa tsiku usadutse 40 mg. Ngati kutenga Lisinopril pa mlingo waukulu kwambiri sikungathandize, ndizotheka kupereka mankhwala ena.
Kusamala
Zotsutsana ndi kugwiritsa ntchito lisinopril:
- cholowa cha idiopathic edema, Quincke's edema ;
- angioedema m'mbiri;
- mimba ndi lactation;
- kusagwirizana pakati pa zidutswa za mankhwala.
Mosamala, mankhwalawa amalembedwa m'mabuku otsatirawa:
- chithandizo;
- chisamaliro chokwanira;
- matenda osokoneza bongo;
- collagenoses (kuphatikizapo systemic lupus erythematosus, scleroderma);
- hyperkalemia kapena chiopsezo chowonjezereka cha kuchitika kwake (ndi shuga, kugwiritsira ntchito kamodzi kowonjezera, kuperewera kwamtunda);
- hyponatremia kapena kuchepetsa sodium mu zakudya;
- chithandizo;
- kupatsirana kwa impso;
- ukalamba, ndi zina zotero.
Zotsatira za lisinopril:
- mutu, chizungulire;
- zovuta za kugona;
- tachycardia;
- mtima;
- hypotension;
- kuchepetsa magazi a hemoglobin ndi hematocrit;
- chifuwa;
- kunyoza, kusanza;
- kutsekula m'mimba;
- ntchito yowonongeka;
- kuthamanga khungu, ndi zina zotero.
Pa mankhwala ndi lisinopril ayenera nthawi zonse kuyang'anira chiwindi ntchito, potaziyamu ndi electrolytes ena m'magazi a seramu, magazi a magazi.