Zamoyo zonse zomwe zili m'thupi la munthu zimayang'aniridwa ndi mahomoni. Mankhwalawa amakhudza osati zakuthupi zokha, komabe komanso maganizo, makamaka kwa amayi. Ngakhale kutaya pang'ono kwa endocrine kusinthika kuchokera ku chikhalidwe kungathe kuwononga kwambiri thanzi labwino ndikumayambitsa mavuto aakulu.
Hormone yotulutsa chithokomiro - Ichi ndi chiyani mwa akazi?
Mankhwala omwe amafotokozedwa amawatulutsa m'kati mwa planditary gland, kusungunula kwake kumayendetsedwa ndi dongosolo loyamba la mitsempha (makamaka mbali). Mahomoni TSH kapena thyrotropin ndi glycoprotein yomwe ili ndi zotsatira zotsatira pa thupi lachikazi:
- kuyendetsa kupanga T3 (triiodothyronine) ndi T4 ( thyroxine );
- malamulo a msambo, ntchito zobereka komanso umoyo wamatumbo;
- kuonetsetsa kuti mphamvu ya thupi ikuyenda bwino;
- kutenga nawo mbali pa vitamini A, phospholipids, acucleic acid ndi mapuloteni;
- normalization ya ntchito ya ziwalo za maso, kumva, mtima ndi machitidwe a mantha;
- Kupititsa patsogolo ayodini kufanana ndi maselo a chithokomiro;
- kukhazikika kwa kusintha kwa maganizo pamaganizo.
Kawirikawiri, pali chithunzi cholakwika T3, T4 ndi TTG. Ndi kuwonjezeka kapena kuchepa kwakukulu m'kati mwa triiodothyronine ndi thyroxine m'magazi a m'magazi, chithokomiro cha chithokomiro chimaimira kusamvana kwapadera. Chotsatira chake, kukula kwake kwa thyrotropin kumasiyana, kotero kuti matenda oyenerera ndi ofunikira kudziwa kuti chiwerengero cha mankhwalawa ndi otani.
Kufufuza kwa mahomoni - TTG
Mankhwalawa amadziwika ndi kusintha kwa tsiku ndi tsiku nthawi zonse. Kuposa kwake kuchuluka kwa plasma kumachitika pakati pa maola awiri ndi awiri usiku. Pakati pa 6-8 am, thyrotropin imayamba kuchepa, imakhala yochepa madzulo, choncho magazi pa TTG ndi abwino kutenga m'mawa. Mukakhala maso usiku, kutulutsa ma hormoni ndikovuta kwambiri.
Kukonzekera kwa kupereka magazi kwa TTG
Kuti muzindikire bwinobwino thyrotropin, zotsatira zake zonse zomwe zingakhudze zotsatira za phunzirolo zisachoke. Akatswiri amalangiza m'mawa kuti atenge TTG - kuyesa magazi kumayambiriro kumbuyo kudzakuthandizani kupeza mtengo wodalirika, pafupi ndipafupi. Ndikofunika kukhala ndi tulo tomwe tisanayambe kupita ku labotori, mwinamwake kudalirika kwa phunziroli kudzachepa.
Musanayambe magazi a TTG, muyenera:
- Musadye maola 8.
- Pewani kusuta pa tsiku la phunziro.
- Madzulo a ulendo wopita ku labotale, muzisankha zakudya zophweka, ndipo musadye bwino.
- Pewani kukhumudwa mwakuthupi ndi m'maganizo.
- Musamamwe mowa kwa masiku asanu musanayambe kufufuza.
Thyropiro hormone ndi yachibadwa kwa amayi
Mu ma laboratori osiyanasiyana, zikhalidwe za mafotokozedwe osiyana zimasiyana malinga ndi mphamvu za zipangizo, choncho ndizozoloŵera kufotokoza zizindikiro zowonetsera. TTG - chizoloŵezi cha amayi pofika zaka (mIU / l):
- 14-25 - 0,6-4,5;
- Zaka 26-50 - 0.4-4.0;
- pambuyo pa zaka 51 - mpaka 4,5.
Chisamaliro chapadera kwa thyrotropin chiyenera kuperekedwa kwa amayi, kufikira kufika zaka 40. Nthawi imeneyi imayambanso kusamba, kotero kulephera kwa mahomoni ndi mavuto okhudzana ndi matendawa. Pambuyo pa kutha kwa thupi, nkofunikanso kuyang'anitsitsa mlingo wa TSH - chizoloŵezi cha chizindikiro ichi sayenera kupitirira malire a 0.4-4.5 mIU / l. Kuwonjezeka kapena kuchepa kwa thyrotropin kumadza ndi matenda akuluakulu a chithokomiro komanso machitidwe omwe amawatsogolera.
TTG imakulira kapena kuwonjezeka - zimatanthauzanji kwa amayi?
Kuwonjezeka kwa pang'onopang'ono kamodzi kambirimbiri kamene kamaperekedwa kameneko kumawonekeranso ndi madokotala monga chosiyana ndi chizolowezi. Mahomoni otulutsa chithokomiro amakulira m'mikhalidwe yovomerezeka pambuyo pa zikhalidwe zoterezi:
- kusowa tulo;
- kukhutira thupi;
- kupanikizika kapena kukhumudwa;
- kuphwanya malamulo okonzekera kusanthula;
- kugwiritsa ntchito kwambiri ayodini.
TTG imakwezeka - zimayambitsa
Ngati thyrotropin m'magazi a m'magazi ndi apamwamba kwambiri kuposa ozolowereka, muyenera kulankhulana ndi otchedwa endocrinologist. Katswiri yekha ndi amene angadziwe chifukwa chake mahomoni otulutsa chithokomiro ali okwera - zomwe zikutanthawuza, sizingatsimikizidwe potsatira zotsatira za kusanthula kokha ndi kufufuza thupi. Kuti mudziwe zenizeni zomwe zimayambitsa vutoli, muyenera kufufuza ndikupeza zozama za T3 ndi T4.
Pali zinthu zambiri zomwe zimakhudza mahomoni otulutsa chithokomiro.
- kutupa kwa chithokomiro;
- chithandizo ;
- poizoni ndi mankhwala otsogolera;
- malipiro oyambirira omwe amadalitsidwa;
- matenda aakulu;
- chitetezo cha minofu ku mahomoni a chithokomiro;
- ziphuphu;
- gestosis ;
- zovuta za dongosolo lalikulu la mitsempha;
- Hashimoto's thyroiditis ndi ena.
TTG imakwezedwa - mankhwala
Thandizo la vuto ili limachokera ku zowonongeka, zomwe zimaphatikizapo timadzi timene timatulutsa timadzi tokoma komanso thyroxine. Kubwezeretsanso vutoli kumapangitsa kuti T4 iwonongeke. Pamene TSH ikukwera, katswiri wamaphunziro a zachipatala amanena kuti kumwa mankhwala ndi thyroxine. Mlingo, kawirikawiri yogwiritsiridwa ntchito ndi nthawi yayitali kwa amayi akuwerengedwa payekha. Kukonzekera kokwanira:
- Bagotiroks;
- Chosayenera;
- Euterox;
- Zosangalatsa;
- L-thyroxine ndi zofanana.
Hormone yotulutsa chithokomiro imatsitsa - imatanthauzanji?
Monga momwe chiwerengero cha kuwonjezeka, kuchepa pang'ono mu kuchuluka kwa TSH sikuli chizindikiro choopsa. Kwa amayi, vutoli nthawi zina limakhala ndi kusintha kwa msambo. Kutsika kwa TSH monga zosiyana ndi zomwe zimachitika kumapezeka motsutsana ndi zifukwa zina:
- njala kapena kutsatila zakudya zolepheretsa kulemera;
- kugwiritsa ntchito mankhwala osokoneza bongo;
- kupsinjika kumapeto kwa kusanthula;
- Kugwiritsa ntchito molakwika mankhwala osokoneza bongo.
TTG inatsika - zifukwa
Ngati mlingo wa mankhwalawa ndi wochepa kwambiri kusiyana ndi chizoloŵezi, ndikofunika kukachezera dokotala mwamsanga. Matenda ndi matenda omwe chithokomiro chothandizira kutulutsa chithokomiro chimachepetsedwa:
- zotupa za chithokomiro;
- encephalitis;
- Matenda a Itenko-Cushing;
- kupweteka;
- Matenda a Grevs;
- Matenda a Shihan;
- zipsyinjo mu chigoba cha pituitary;
- chonchi;
- Matenda a Plummer;
- kudandaula ndi ena.
TTG imatsitsa - mankhwala
Kuonetsetsa kuti tizilombo toyambitsa magazi mumayambitsa matenda a m'magazi, m'pofunikira kuthana ndi matenda oopsa komanso mofanana ndi kugwiritsa ntchito mahomoni othandizira. Mlingo wa TSH ukhoza kuwonjezeredwa ndi mankhwala apadera, omwe amaperekedwa ndi wodwala okhaokha:
- Parasosin;
- Amiodarone;
- Methimazole;
- The ipodeyt;
- Erythrosine ndi zofanana.
TTG mu mimba
M'mayi am'mbuyo, machitidwe a endocrine amagwira ntchito mosiyana, chifukwa mahomoni a mwanayo sanapangidwe. Kuchokera nthawi yogonana ndi chiwerengero cha mazira, kutentha kwa TSH - chizoloŵezi cha amayi omwe akukonzekera maonekedwe a mwana (mIU / l) chimadalira:
- 1 trimester - mpaka 0,4;
- 2 trimester - 0,3-2,8;
- 3 trimester - mpaka 3,5.
Pambuyo pathupi, kutsika pang'ono mu thyrotropin ndi khalidwe. Izi ndi chifukwa cha kuchulukitsidwa kwa magazi kwa chithokomiro, choncho chifukwa chake T3 ndi T4 zimayambitsidwa. Potsutsana ndi maganizo olakwika, kuwonjezereka kwa ndondomeko yawo kumabweretsa kuthetsa kusinthika kwa mahomoni omwe akufotokozedwa. Ngati pali fetus zingapo m'mimba, chizindikiro ichi chikhoza kufanana ndi zero.
Ngati TTG ikukweza mimba, m'pofunikanso kupitanso kachiyeso kachiwiri ndikuyendera katswiri wamakono. Matenda ambiri a thyrotropin ndi owopsa kwa mwanayo ndipo nthawi zambiri amachititsa mavuto a kugonana, kuletsa chitukuko cha mwana wosabadwayo. Kuonetsetsa kuti msinkhu wa TSH uli ndi amayi omwe akukonzekera kubereka, mankhwala apadera akulamulidwa:
- levothyroxine sodium;
- Bagotiroks;
- L-thyroxine;
- Tiro-4;
- L-Tirok ndi zofanana.