Mwazi wa anthu umaphatikizapo mitundu yambiri ya mapuloteni, omwe ayenera kukhala mu chiŵerengero china kuti achite ntchito zawo. Mmodzi mwa iwo ndi fibrinogen, kuchuluka kwake komwe kumatsimikiziridwa muyezo woyenera wa magazi pofuna kutseka. Ngati zotsatira za fibrinogen ndi zazikulu kuposa zachibadwa, izi zikutanthauzanji, ndikofunikira kudziwa.
Fibrinogen - ndi chiyani?
Ndipotu, kodi fibrinogen ndi chiyani, odwala ambiri amakondwera pamene akuwona zotsatira za coagulogram - kafukufuku wa ma laboratory a magazi oopsa, omwe amalola munthu kuyesa mphamvu yake yogwiritsira ntchito. Kawirikawiri, kusanthula kumeneku kumaperekedwa musanayambe kuchita opaleshoni zosiyanasiyana, panthawi ya mimba, ndikukayikira matenda ena (chiwindi, mtima, mitsempha, etc.).
Mapuloteni fibrinogen amapangidwa ndi chiwindi cha chiwindi ndipo, kulowa m'magazi, amakazungulira mumtunda wosasinthika. Ndi chimodzi mwa zinthu zomwe zimayambitsa magazi. Chifukwa cha zovuta zomwe zimachitika poyankha zotsatira zoopsa, chotengera chokhudzidwacho chimatsekedwa ndi chovala chomwe chimasiya kutuluka magazi. Chifukwa chopanga clot (thrombus) ndi mankhwala osakanikirana a fibrin, omwe amapangidwa ndi kugawidwa kwa fibrinogen mwa kupangitsa tizilombo toyambitsa matenda.
Kuphatikizidwa kutenga nawo mbali pa mapangidwe a thrombus, fibrinogen amalimbikitsa mapangidwe atsopano a vesicles ndi machitidwe apakompyuta, komanso amatanthauzira zotupa. Kuchepetsa m'mimba mwake kumapangitsa kuti magazi asamawonongeke, omwe amachititsa kuti magazi azimalika kwa nthawi yayitali, ndipo kutsika kwa fibrinogen kumapangitsa kuti pakhale maonekedwe osakanikirana a thrombi ngakhale popanda kuwonongeka kwa makoma aakulu.
Kusankha kwa fibrinogen
Mu ma laboratories, fibrinogen m'magazi amadziwika ndi njira zamagetsi. Pofuna kupewa zolakwika, zikhalidwe zotsatirazi ziyenera kuwonetsedwa musanakhale zitsanzo:
- kusamutsa tsiku lophunzira ngati pali mawonetseredwe a matenda a catarrhal;
- kusala kudya, kumwa khofi, tiyi, zakumwa zoledzeretsa 12 maola asanachitike;
- kuthetseratu kwa kayendetsedwe ka mankhwala osokoneza bongo omwe amakhudza magazi, masiku angapo musanaphunzire (motsogozedwa ndi dokotala);
- Kulepheretsa thupi, kusokonezeka maganizo pamaso pa kusanthula;
- kukana kusuta osachepera maola angapo;
- Kutenga galasi la madzi oyera kwa kotala la ola musanamwe magazi.
Fibrinogeni m'magazi - kawirikawiri mwa amayi
Fibrinogeni m'magazi, yomwe nthawi zambiri imadalira msinkhu wa munthu, iyenera kusungidwa ndi kuchuluka kwa 2-4 g / l mwa amayi achikulire omwe ali ndi thanzi labwino, komanso amuna. Kwa ana, mitengoyi ndi yochepa. Ngati, malinga ndi zotsatira za kafukufuku wa fibrinogen, chizoloŵezi cha amayi chimawonedwa, izi zikutanthauza kuti mapuloteni awa amapangidwa mokwanira, kuchuluka kwa luso la magazi sikuphwanyidwa.
Fibrinogen mu mimba ndi yachilendo
Fibrinogen, yomwe nthawi zambiri imakhala yosasunthika kwa anthu abwinobwino, amasintha njira yake yoyenera pamene mkazi atenga mwana. Izi zimachokera ku mapangidwe a thupi la mayi la dongosolo latsopano lozungulira, lomwe lili ndi placenta. Poyambirira, mlingo wa mapuloteniwa sumawonjezeka kwambiri, koma m'zaka zitatu zapitazi, fibrinogen mwa amayi omwe ali ndi pakati akufika pachimake, chomwe chili chofunikira kuteteza magazi ambiri pa nthawi yobereka. Makhalidwe ndi awa:
- Ndili ndi trimester - 2,5-5 g / l;
- II trimester - 2.5-5.1 g / l;
- III trimester - 3.7-6.1 g / l.
Fibrinogen yowonjezereka - imatanthauzanji?
Pamene kafukufuku akuwonetsa kuti fibrinogen ndi yapamwamba kuposa yachibadwa, zikutanthauza kuti wodwala ali ndi mwayi wochulukirapo wa thrombosis - kupezeka kwa kayendedwe kabwino ka magazi pamtundu wina kapena gawo lina la thupi. Matendawa amalepheretsa kukula kwa matenda a mtima, myocardial infarction, stroke, e.e. zoopsa kwambiri pathologies.
Nthawi zina fibrinogen ikhoza kuwonjezeka pang'ono kapena kanthawi mwazifukwa izi:
- kusamba;
- ntchito yoyamba yothandizira;
- zotentha zamakono, zoopsa zina;
- otsika yozungulira kutentha.
Kuphatikiza apo, fibrinogen ndi yapamwamba kuposa yachibadwa mwa amayi omwe amatenga mankhwala a estrogen. Zovuta kwambiri kuposa momwe nthawi yaitali yogwiritsira ntchito fibrinogen imakhala yochuluka kwambiri kuposa yachibadwa, ndipo izi zikutanthauza kuti kutupa kapena njira zina zowonongeka zimachitika m'thupi. Zomwe zimayambitsa ndi:
- Matenda akuluakulu opatsirana komanso opatsirana omwe amapezeka m'madera osiyanasiyana (TB, pyelonephritis, pancreatitis, etc.);
- zovuta zopweteka;
- mitundu yosiyanasiyana ya hypothyroidism ;
- Kufa kwa ziphuphu (pancreatic necrosis, kupuma kwa mapapo , ziphuphu, etc.);
- Matenda omwe amachititsa kuti thupi liziyenda bwino (nyamakazi ya nyamakazi);
- Kuwonongeka kwa zombo zowopsa (matenda a shuga a angiopathy, kusadziwika koopsa kwa mitsempha, mitsempha ya varicose, etc.);
- matenda a thrombohemorrhagic (siteji yoyamba);
- kupweteka kwa amyloid, etc.
Fibrinogen imakwezeka mimba
Ngati fibrinogen pa nthawi yoyembekezera imapitirira kuposa malire apamwamba, zifukwa zingakhale zofanana. Matendawa sagwiritse ntchito thanzi komanso moyo wa mayi wam'mbuyo mtsogolo, komanso amachititsa kuti pakhale mimba. Zotsatira zake zikhoza kukhala motere:
- kupatuka kwadzidzidzi;
- kusokonezeka mwatsatanetsatane;
- thrombosis ya umbilical chingwe;
- kubadwa msanga, ndi zina zotchedwa fibrinogen pamwamba pa chizoloŵezi chomwe chimatanthauza fibrinogen pamwamba pa chizolowezi aaa chomwe chimatanthauza
Firinogen yakula - chochita chiyani?
Nthawi zina kuwonjezeka kwa fibrinogen kumapezeka, nkofunika kuyesa mayeso ena kuti adziwe chomwe chimayambitsa matendawa. Pokhapokha izi zitatsimikiziridwa ndi ndondomeko yokhayokha, yomwe cholinga chake ndi kukonza matenda ovuta. Pofuna kupatsirana mwadzidzidzi kuchuluka kwa mapuloteniwa, mankhwala ochokera ku gulu la antiplatelet agents , fibrinolytics, antiticoagulants akhoza kuuzidwa, zakudya ndi kuchepetsa kudya kwa kolesterolini, kuchita masewera olimbitsa thupi tsiku ndi tsiku, kuyendetsa bwino kumwa moyenera kumalimbikitsidwa.