Cordarone ya mankhwala ndi zizindikiro zake zonse ndi zotsutsana zomwe zingagwiritsidwe ntchito ndi gulu la mankhwala osokoneza bongo a m'kalasi lachitatu. Izi zikutanthauza kuti ntchitoyi imapangidwira njira zowonjezera potaziyamu. Mankhwalawa ali ndi zida za antiarrhymics za kalasi yoyamba ndi yachinayi. Ndipo, motero, ikhoza kuyika njira imodzi ya sodium ndi calcium. Mwazinthu zina, mankhwalawa ali ndi beta-adrenergic, omwe amatsutsana ndi anginal ndi zotsatira zake zochepa.
Zisonyezo za kugwiritsa ntchito mapiritsi a Kordaron
Chifukwa cha mankhwala ndi amiodarone hydrochloride. Mlingo woyenera wa chogwiritsidwa ntchito ndi 200 mg. Kuwonjezera pa izo, zomwe zikukonzekerazi zikuphatikizapo zigawo zothandizira:
- anhydrous colloidal silicon dioxide;
- lactose monohydrate;
- magnesium stearate;
- chimanga cha chimanga;
- Povidone.
Mankhwala a Cordarone amasonyeza kuti amagwiritsidwa ntchito pa chithandizo cha mankhwala komanso chifukwa cha mankhwala. Ikani kawirikawiri pa:
- supraventricular paroxysmal tachcarcaras;
- chithumwa;
- Matenda a Wolff-Parkinson-White;
- choponderezeka ndi ventricular extrasystole ;
- mphepo yamkuntho;
- sinus tachycardia;
- kupulumuka pambuyo pa matenda a myocardial infarction;
- gawo lalikulu la myocardial infarction;
- matenda oopsa;
- kuphwanya ntchito za ventricle;
- chithandizo;
- kuthamanga kwa angina pectoris .
Momwe mungagwiritsire ntchito mapiritsi a Kordaron amatsimikiziridwa ndi dokotala yemwe akupezekapo. Mankhwala osiyana angagwiritsidwe ntchito pa mankhwala. Mwachitsanzo, mwachilombo cha matenda osapatsirana, mlingo woyenerera woyambira ndi 600-800 mg wa amiodarone hydrochloride, wogawidwa m'mayeso angapo. Mlingo wochuluka wololedwa tsiku lililonse ndi 10 g ndipo mankhwalawa amatha masiku asanu kapena asanu ndi atatu.
Chiwembu cha mankhwala ochiritsira kuchipatala ndi ofanana, koma chiyenera kukhala patali pang'ono - kuyambira masiku khumi mpaka masabata awiri. Ndikofunika kukumbukira kuti kutalika kwa theka la moyo wa Kordaron sizitali kwambiri, choncho ndibwino kuti muzigwiritsa ntchito tsiku lililonse. Mukhozanso kumwa mapiritsi ochepa - mpaka masiku angapo - zosokoneza.
Yambani kuchipatala onse akatswiri amalangiza ndi mlingo wocheperako ndikuwongolera zotsatira za kuchiritsidwa. Ngati mankhwalawa sali okwanira, ndiye kuti mlingo uyenera kuwonjezeka.
Zotsutsana ndi kugwiritsa ntchito Cordarone
Mankhwala otsutsana ndi pafupifupi mankhwala aliwonse. Ndipo Cordaron sizinali zosiyana. Sichikulimbikitsidwa kuti muzitha kuchiritsidwa ndi mankhwala osokoneza bongo pamene:
- hypersensitivity kwa zigawo zowonjezera;
- Kuchulukitsa nthawi ya QT (onse okhudzidwa ndi opezeka);
- sinus bradycardia;
- sinoatrial yatsekedwa;
- mimba;
- kuyamwitsa;
- matenda a m'mapapo;
- hypokalemia;
- chithunzithunzi;
- Matenda a chithokomiro (monga hyper- kapena hypothyroidism);
- atrioventicular yamasulidwa kuchoka pa zoyamba kufika pachitatu.
Ana sayenera kumwa mapiritsi asanafike khumi ndi zisanu ndi zitatu. Modzichepetsa kwambiri, Cordarone iyenera kuperekedwa kwa odwala omwe ali ndi:
- choyimitsa;
- kupatsirana kapena kulephera mtima mtima;
- kusokonezeka kwa mtima;
- mphutsi yamoto;
- mtima;
- chidziwitso chodziletsa.
Tengani mankhwala poyang'aniridwa ndi katswiri, komanso odwala okalamba omwe thupi lawo limafooka chifukwa cha kusintha kwa msinkhu komanso kuwonetseka.
Ndizovuta kwambiri kuphatikiza Cordarone ndi mankhwala:
- Quinidine;
- Chonchi;
- Quinine;
- Pimozide;
- Fluphenazine;
- Mzimu;
- Misolastine;
- Sultopride;
- Terfenadine;
- Haloperidol;
- Bretilia;
- Sotalol;
- Mzimu;
- Chlorpromazine;
- Ciammazine.