Indomethacin ndi mankhwala omwe amapezeka m'njira zosiyanasiyana kuti azitha kugwiritsa ntchito mapulogalamu. Tiyeni tikambirane mwatsatanetsatane, zomwe zimapangitsa mapiritsiwa kuti azilemba, pamene akugwira ntchito, ndi zotsutsana ndi zotsatira zotani zomwe ali nazo.
Mapangidwe ndi mapiritsi a mapiritsi Indomethacin
Mankhwalawa ndi a gulu la mankhwala osagwiritsa ntchito steroidal anti-inflammatory and antirheumatic. Monga gawo lalikulu, liri ndi chinthu chomwecho ndi dzina lomwelo, chomwe chimachokera mu indoleacetic asidi. Monga zowonjezerapo, mapiritsi, malingana ndi wopanga, angakhale nawo: wowuma, silicon dioxide, lactose, talc, cellulose, sodium lauryl sulphate, ndi zina zotero. Mapiritsi amavala ndi malaya amkati omwe amaletsa kusokoneza kwa mankhwala m'mimba.
Ma pharmacological mankhwala a mankhwala awa ndi awa:
- anti-inflammatory;
- kupweteka;
- antipyretic.
Zotsatira zochiritsira zimenezi zimachokera ku kulepheretsa mavitamini a cyclooxygenase, omwe ali m'magulu osiyanasiyana a thupi ndipo ali ndi udindo wophatikizapo prostaglandin. Prostaglandins amachititsa ululu pakhungu, kutentha kwawonjezeka komanso kuwonjezeka kwa ziphuphu, choncho chifukwa cha kuchepa kwawo, zizindikirozi zimachotsedwa.
Mankhwalawa amachititsa kufooketsa kapena kuthetsa vuto lopwetekedwa ndi matenda osagwiritsidwa ntchito, kuphatikizapo kumakhudza kupweteka kwapadera pa ntchito komanso ntchito. Komanso, amachepetsa kuuma kwa ziwalo, kuwonjezera kuchuluka kwa kayendetsedwe kake, kumenyana ndi kutupa.
Zizindikiro zogwiritsira ntchito mapiritsi Indomethacin
Mapiritsiwa amalembedwa kuti azisamalidwa bwino ndi zotsatirazi:
- Matenda opweteka ndi osowa m'thupi (matenda a rhumum, nyamakazi ya Bechterew, matenda a Reiter, nyamakazi yambiri, psematic arthritis, etc.);
- zilonda zamatenda (perioticular tissues) (bursitis, tendonitis, tendovaginitis, etc.);
- ululu chifukwa cha zilonda zopweteketsa ndi njira zopangira opaleshoni;
- chisamaliro;
- radiculoneuritis;
- plexite;
- dysmenorrhea;
- adnexitis ;
- Matenda opatsirana ndi otupa a ziwalo za ENT, ndi zina zotero.
Mapiritsi amatengedwa pambuyo pa chakudya kapena panthawi yake m'magawo ena, malinga ndi mtundu wa matenda ndi kuuma kwake.
Zotsatira za indomethacin
Pochiza Indomethacin m'mapiritsi, zochitika zotsatirazi zikhoza kuchitika:
- chisokonezo;
- ululu wamimba;
- kusanza;
- zovuta;
- mutu;
- magazi m'matumbo;
- kugona;
- kuwonjezeka kwa magazi;
- kusokonezeka kwa mtima;
- kuyabwa;
- urticaria;
- magazi ;
- masomphenya;
- kukwiya, ndi zina zotero.
Mapepala osiyana siyana Indomethacin
Mankhwala Indomethacin mu mapiritsi saloledwa muzochitika zoterezi:
- hypersensitivity kwa zigawo zikuluzikulu za wothandizila;
- Kukhalapo kwa anamnesis wa momwe amachitira ndi acetylsalicylic acid kapena mankhwala ena odana ndi kutupa ndi mawonetseredwe a masewero a asthmatic, angioedema, mng'oma, rhinitis;
- ululu;
- Kukhalapo kwa mbiri ya m'mimba kutuluka mwa magazi kapena kuperewera kwa mankhwala chifukwa cha kugwiritsidwa ntchito kwa mankhwala osagwiritsa ntchito steroidal anti-inflammatory;
- mtima wolephera;
- chiwindi chachikulu kapena kuperewera kwa impso;
- mimba;
- nthawi ya lactation.
Pa chithandizo ndi indomethacin, ndi bwino kuyang'anira chiwindi ndi impso, chiwerengero cha magazi.