17-OH progesterone kapena 17-hydroxyprogesterone ndi hormone ya steroid yomwe imapangidwa kuchokera ku zinthu zamtundu wa adrenal gland ndipo imakhala yowonongeka kwa mahomoni monga cortisol, estradiol ndi testosterone. Zimapangidwanso m'magulu a kugonana, kupunduka kokhwima, chikasu thupi ndi placenta ndipo motsogoleredwa ndi enzyme 17-20 lyase amasanduka mahomoni ogonana. Kenaka, tikambirana momwe progesterone 17 imathandizira thupi la mayi wosayembekezera komanso pathupi ndi zizindikiro za kuwonjezeka kwake ndi kusakwanira.
Tizilombo toyambitsa matenda 17-oh progesterone
Momwe munthu aliyense aliri ndi 17-OH progesterone amasinthasintha mkati mwa maola 24. Choncho, maulendo ake otchulidwa m'mawa amapezeka m'maola ammawa, ndipo osachepera - usiku. 17-OH progesterone mwa amayi amasiyana malinga ndi nthawi ya msambo. Kuwonjezeka kwakukulu kwa mlingo wa hormone iyi kumatchulidwa madzulo a ovulation (chisanafike kuwonjezeka kwakukulu kwa homoni ya luteinizing). 17-OH progesterone mu follicular gawo imachepa mofulumira, kufika pamlingo wocheperapo mu chiwopsezo.
Tsopano ganizirani zoyenera za 17-OH progesterone, malingana ndi gawo la kusamba:
- mu gawo la luteal - 0.99-11.51 nmol / l;
- mu follicular phase - 1,24-8,24 nmol / l;
- mu gawo la ovulation - 0,91-4,24 nmol / l.
17-OH progesterone mimba imawonjezeka, kufika pamtengo wake wapatali m'masabata apitawo. Pakati pa mimba, placenta imayanjananso ndi kaphatikizidwe ka homoni iyi. Talingalirani mtengo wovomerezeka wa 17-OH progesterone pa nthawi yoyembekezera:
- mu trimester yoyamba - 3,55-17,03 nmol / l;
- mu trimester yachiwiri - 3,55-20 nmol / l;
- mu 3 trimester - 3.75-33.33 nmol / l.
Poyambitsa matendawa komanso pakapita nthawi, mlingo wa hormone 17-OH progesterone umachepa kwambiri ndipo umatha kufika ku 0.39-1.55 nmol / l.
Sinthani mlingo wa 17-OH progesterone - matenda ndi matenda
Mafupa osakwanira a 17-OH progesterone m'magazi nthawi zambiri amachititsa adrenal hypoplasia ndipo akhoza kuphatikizidwa ndi kusakwanira kokwanira kwa mahomoni ena. Pachipatala, icho chikhoza kudziwonetsera nokha mwa mawonekedwe a matenda a Addison, ndipo anyamata sakulimbitsa thupi lakunja.
Kuwonjezereka kwa 17-OH progesterone kungathe kuwonedwa pokhapokha pa mimba, nthawi zina zimasonyeza matenda. Choncho, 17-OH progesterone ikhoza kukhala chizindikiro cha zotupa zowonjezera, mazira ambiri (maonekedwe opweteka ndi polycystosis) ndi matenda a chiberekero cha adrenal cortex.
Kachilombo, kuwonjezeka kwa 17-OH progesterone kungawonetseredwe:
- Kuphwanya kwa msambo;
- kusowa;
- zochotsa mimba;
- kubadwa kapena kufa kwachinyamata;
- kuwonjezera kwa progesterone 17-OH ikhoza kuwonetsedwa ndi ziphuphu (ziphuphu);
- Ngati 17-OH progesterone ikukwera, testosterone ikhozanso kukwezedwa. Izi zikhoza kuwonetsedwa ngati mawonekedwe a kukula kwa tsitsi pamaso ndi thupi (mtundu wa tsitsi la amuna).
Mlingo wa 17-OH progesterone ukhoza kutsimikiziridwa pofufuza seramu
Choncho, tinayang'ana mbali yomwe imapezeka mu thupi la hormone 17-OH progesterone ndi chikhalidwe chake chovomerezeka kwa amayi. Kutsika kwa mlingo wa homoniyi kungakhale kokha panthawi ya kusamba, ndipo kuwonjezeka kwake kumawoneka ngati kozolowereka panthawi yonse ya mimba. Kusintha kwa msinkhu wa 17-OH progesterone m'madera ena ukhoza kukhala chimodzi mwa zizindikiro za matenda osokoneza bongo ndi ovari, omwe amachititsa hyperandrogenism, kusabereka kapena kuchotsa mimba.