Aminoglycosides akuphatikizapo gulu la maantibayotiki omwe amadziwika ndi mawonekedwe ofanana, chikhalidwe chochita ndi poizoni wapamwamba. Kukonzekera kwa aminoglycoside ali ndi mankhwala omveka bwino a antimicrobial ndipo akutsutsana ndi mabakiteriya a Gram-positive ndi Gram-negative.
Chiwerengero cha aminoglycosides
Malingana ndi munda wogwiritsira ntchito komanso kuchuluka kwa chitukuko cha kukana, mibadwo inayi ya mankhwala ndi mankhwala. Tiyeni tione zomwe zimayambira ndipo tidzakwaniritsa mndandanda wa mayina okonzekera-aminoglycosides.
Mbadwo Woyamba wa Mankhwala
Izi ndi izi:
- Neomycin;
- Streptocin;
- Monomycin;
- Kanazin.
Amagwiritsidwa ntchito pakuthana ndi tizilombo toyambitsa matenda a chifuwa chachikulu komanso mabakiteriya ena. Kulimbana ndi staphylococci ndi mabakiteriya ambiri a gram, mankhwala alibe mphamvu. Tsopano iwo samagwiritsa ntchito.
Aminoglycosides a m'badwo wachiwiri
Woimira gulu lachiwiri la maantibayotiki-aminoglycosides ndi Gentamicin, omwe amagwira ntchito kwambiri kuposa gulu lakale la mankhwala.
M'badwo wachitatu wa aminoglycosides
Zomwe zimachitika m'badwo wachitatu zikufanana ndi Gentamycin, komabe zimagwira ntchito motsutsana ndi enterobacter, klebiciella ndi Pseudomonas aeruginosa . Gululi likuphatikizapo:
- Sisomycin;
- Tobramycin;
- Amicacin.
M'badwo wachinayi
Gululi limaphatikizapo ma antibiotic Izepamycin, omwe amatha kulimbana ndi nocardia, cytobacter, aeromonas.
Zotsatira za aminoglycosides
Pa nthawi ya mankhwala ndi mankhwalawa, wodwalayo akhoza kukumana ndi zovuta zambiri zosavuta. Mankhwala ovuta kwambiri a mankhwalawa ndi poizoni. Zikuwonekera mu mawonetseredwe otsatirawa:
- Ototoxicity, yomwe imabweretsa kugwedeza kwakumva, kuoneka phokoso m'makutu, kumverera kosavuta.
- Mpweya wa Nephrotoxic, zizindikiro zomwe zimakhala ndi ludzu, kusintha kwa mkodzo, kuchepetsa kusungunuka kwa glomerular.
- Kusokonezeka kwa kayendetsedwe ka kayendetsedwe kake ndi chizungulire, chomwe chiri makamaka khalidwe la okalamba.
- Mbali ya mitsempha ya mantha, kupweteka pakamwa, kusowa, kufooka, kupweteka mutu, kugwedezeka kochititsa mantha, kugona kumatchulidwa.
- Kuwoneka kwa zizindikiro za matenda a neuromuscular blockade, kuwonetseredwa kuwonjezereka kwa kupuma kumene kumafika mpaka ku ziwalo zochititsa khunyu zomwe zimayambitsa kupuma kwa minofu, kumawonjezera chiopsezo ndi machitidwe ofanana a antibiotics-aminoglycosides ndi minofu yopumula ndi anesthetics, komanso kupatsiridwa kwa magazi a citrated.
Zizindikilo zosavomerezeka sizodziwika.